Markers of Inflammation and Prostate Cancer Risk

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

FR Schumacher, AA Al Olama, SI Berndt, S Benlloch, M Ahmed, EJ Saunders, T Dadaev, D Leongamornlert, E Anokian, C Cieza-Borrella, C Goh, MN Brook, X Sheng, L Fachal, J Dennis, J Tyrer, K Muir, A Lophatananon, VL Stevens, SM Gapstur

2018-07-01

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susce..

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia

F Gu, H Zhang, PL Hyland, S Berndt, SM Gapstur, W Wheeler, CI Amos, S Bezieau, H Bickeböller, H Brenner, P Brennan, J Chang-Claude, DV Conti, JA Doherty, SB Gruber, TA Harrison, RB Hayes, M Hoffmeister, RS Houlston, RJ Hung

2017-11-01

Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic varia..

Use of a novel nonparametric version of DEPTH to identify genomic regions associated with prostate cancer risk

RJ MacInnis, DF Schmidt, E Makalic, G Severi, LM FitzGerald, M Reumann, MK Kapuscinski, A Kowalczyk, Z Zhou, B Goudey, G Qian, QM Bui, DJ Park, A Freeman, MC Southey, AAA Olama, Z Kote-Jarai, RA Eeles, JL Hopper, GG Giles

2016-12-01

Background: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the numbe..

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

A Gusev, H Shi, G Kichaev, M Pomerantz, F Li, HW Long, SA Ingles, RA Kittles, SS Strom, BA Rybicki, B Nemesure, WB Isaacs, W Zheng, CA Pettaway, ED Yeboah, Y Tettey, RB Biritwum, AA Adjei, E Tay, A Truelove

2016-04-07

Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer..

A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease

G Severi, LM Fitzgerald, DC Muller, J Pedersen, A Longano, MC Southey, JL Hopper, DR English, GG Giles, J Mills

2014-10-01

Only a minority of prostate cancers lead to death. Because no tissue biomarkers of aggressiveness other than Gleason score are ava..

Interleukin-6 promoter variants, prostate cancer risk, and survival

EA Tindall, G Severi, HN Hoang, MC Southey, DR English, JL Hopper, GG Giles, VM Hayes

2012-12-01

Background. Inflammation has been implicated in prostate cancer (PCa) pathogenesis. Promoter DNA variants responsible for differen..

Asthma, asthma medications, and prostate cancer risk

G Severi, L Baglietto, DC Muller, DR English, MA Jenkins, MJ Abramson, JA Douglass, JL Hopper, GG Giles

2010-09-01

Background: The aim of this study was to assess whether a history of asthma or the use of asthma medications is associated with pr..

Plasma concentration of Propionibacterium acnes antibodies and prostate cancer risk: Results from an Australian population-based case-control study

G Severi, BA Shannon, HN Hoang, L Baglietto, DR English, JL Hopper, J Pedersen, MC Southey, R Sinclair, RJ Cohen, GG Giles

2010-07-27

Background:Recent studies in prostatic tissue suggest that Propionibacterium acnes (P. acnes), a bacterium associated with acne th..

Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk

EA Tindall, G Severi, HN Hoang, CS Ma, P Fernandez, MC Southey, DR English, JL Hopper, CF Heyns, SG Tangye, GG Giles, VM Hayes

2010-04-19

Although inflammation is emerging as a candidate prostate cancer risk factor, the T-helper cytokine-rich [interleukins (IL)-5, 13 ..

The 4q27 locus and prostate cancer risk

EA Tindall, HN Hoang, MC Southey, DR English, JL Hopper, GG Giles, G Severi, VM Hayes

2010-02-25

Background: Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the fi..